You should also adjust based on what your opponents have in their lineup. You can maybe see a random hero that could get a 3 star, or they can take someone you had planned to do. Note the hero pool. You are not guaranteed to get the hero you want, but every quality of a hero will reduce the amount needed. Legendary Heroes (marked in a yellow text for heroes) only have 9, but Normal Heroes (marked with gray text) have 27 heroes each. This should be an important factor, especially if you are trying to get 3-star heroes outside of the Normal level. In rare cases, your hero will earn a random blessing when upgraded. Their blessing can enhance their stats and can also lower the synergy trigger minimum by one. A percentage counter can be seen when you choose your heroes to where the hero will earn a blessing. Take this as an advantage to complete other synergies!
If you want, you can check the opponents to see what synergy they are activating. It’s best to use Mech Era when most opponents use the Weapon Master synergy. When you max out a synergy (in most cases), you are given two choices to revolutionize the synergy. You can select which one is important to continue winning with your lineup.
You should save as much as possible in the early game to convert it into battle power.
You should choose the equipment first since there can be Synergy equipment (if you need to complete Astro Power/Abyss), or a Science Crystal (important since it increases a lineup without wasting coins). If needed, you can choose the heroes in the pool.